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. 2017 Jun 27;7:4272. doi: 10.1038/s41598-017-04496-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of hBMP-2 addition to MSC therapy on radiation-induced dermatitis repair. (A) Photographs of radiation-induced lesions 7 days after injection. Three groups of animals were irradiated at 55 Gy and received PBS (PBS), MSCs (MSCs), or MSCs and hBMP-2 (MSCs + hBMP-2) infusion three weeks later. (a) PBS treatment, (b) infusion of 2 × 10⁵ MSCs, and (c) co-injection of 2 × 10⁵ MSCs and hBMP-2. (d) % of initial lesion surface area and (e) average lesion scores. PBS (white bars), MSCs (grey bars), or MSCs + hBMP-2 (black bars). (B) One week after treatment, HES staining (a–c) (a) PBS control infusion; (b) local infusion of 2 × 10⁵ MSCs; and (c) hBMP-2 co-infusion with MSCs. (d–f) Masson’s Trichrome staining of: (d) PBS control infusion; (e) local infusion of 2 × 10⁵ MSCs; and (f) hBMP-2 co-infusion with MSCs. Each group of animals comprised 10 Sprague Dawley rats. Comparison by ANOVA followed by the Mann-Whitney or Dunnett’s test for group pair-wise comparisons. Data represent mean ± SEM, ns: not significant, *p < 0.05, **p < 0.01, ***p < 0.001.