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. Author manuscript; available in PMC: 2017 Jun 28.
Published in final edited form as: Chem Rev. 2017 Apr 17;117(11):7276–7330. doi: 10.1021/acs.chemrev.6b00729

Figure 25.

Figure 25

Contextual information on a tagged particle’s microenvironment may be used in linking. In the top panels above, a lysosome (red trajectory) was transported by molecular motors on a microtubule network (green background). By using super-resolution to image the microtubule network with high precision (lower panels), it became possible to closely match a lysosome trajectory to a particular microtubule and quantify when the lysosome detached or switched between microtubules.319 Reproduced with permission from Štefan Bálint, Ione Verdeny Vilanova, Ángel Sandoval Álvarez, and Melike Lakadamyali. “Correlative live-cell and superresolution microscopy reveals cargo transport dynamics at microtubule intersections.” Proceedings of the National Academy of Sciences 110, no. 9 (Feb 26, 2013): 3375−3380.