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. 2017 Jun 28;11:181. doi: 10.3389/fncel.2017.00181

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Copyright © 2017 Lisek, Ferenc, Studzian, Pulaski, Guo, Zylinska and Boczek.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Animal behavior analysis in the open field test. Thirty minutes before behavioral testing, rats were intraperitoneally injected with last (fifth) ketamine dose (30 mg/kg). During the open field test, the total immobility time (A), number of entries in the center area (B), frequency of grooming (C), crossing (D), rearing (E) and sniffing (F) were recorded over 20 min and analyzed with ANY-maze tracking system. n = 16 for the control group (saline-treated); n = 16 for ketamine-treated group. *P < 0.05 ketamine treated vs. saline.