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. 2017 Jun 28;8:722. doi: 10.3389/fimmu.2017.00722

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Copyright © 2017 Kurow, Frey, Schuster, Schmitt, Adam, Hahn, Gilchrist, McInnes, Wirtz, Gaipl, Krönke, Schett, Frey and Hueber.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Full length IL-33 exacerbates irradiation-induced dermatitis. hK14mIL33tg (K14-IL-33) mice were locally irradiated with four single fractions of 12 Gy (cumulative dose of 48 Gy, 6 MV, right ear). This procedure was performed at days 1, 3, 5, and 7 and dermatitis (A) (K14-IL-33 n = 15, WT n = 10) and ear thickness (B) (K14-IL-33 n = 7, WT n = 5) measured as indicated. Two 2 × 2 ANOVAs, each incorporating time as a within-subjects characteristic (difference between first measurement at day 2 and the last measurement at day 25) and group assignment as a between-subjects characteristic (control mice vs. K14 IL33 mice) suggested a significant interaction of time and group assignment for ear thickness (p = 0.016) and a near significant result in view of the clinical score (p = 0.056). These results were retrieved besides the significant single effect of time in both models (p ≤ 0.002).