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. 2017 Jun 28;8:741. doi: 10.3389/fimmu.2017.00741

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Copyright © 2017 Guo, Fang, Li, Xiao, Chen, Wang, Yang, Chen and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of natural killer (NK) cell receptors in decidual NK (dNK) cells of induced abortion (IA) and recurrent spontaneous abortion (RSA). (A) Expressions of NKp46, NKp44, killer immunoglobulin-like receptor 2DL4 (KIR2DL4), NKG2A, NKG2D, immunoglobulin-like transcript 2 (ILT2), and ILT4 on the CD3⁻CD56⁺CD16⁻ dNK cells of the two groups. The gray-filled histograms represent background staining of corresponding isotype-matched control. (B) Percentage of NKp46, NKp44, KIR2DL4, NKG2A, NKG2D, ILT2, and ILT4 on CD3⁻CD56⁺CD16⁻ dNK cells of IA and RSA. (C) Mean fluorescence intensity (MFI) of these receptors on CD3⁻CD56^brightCD16⁻ dNK cells of IA and RSA. (D) Representative density plots showing the KIR2DL4 expression on gated CD3⁻CD56^brightCD16⁻ dNK cells of IA and RSA with intracellular staining. (E) Percentage of KIR2DL4 expression on gated CD3⁻CD56^brightCD16⁻ dNK cells of two groups with intracellular staining. (F) Representative density plots showing CD56^bright and CD56^dim NK cells in gated CD56⁺CD3⁻ NK cells isolated from peripheral blood (pNK) in the first trimester of IA group. (G) Representative density plots showing the KIR2DL4 expression on gated CD3⁻CD56^bright and CD3⁻CD56^dim pNK cells of IA and RSA. (H) Percentage of KIR2DL4 expression on gated CD3⁻CD56^bright and CD3⁻CD56^dim pNK cells of IA and RSA. n = 6 for each group. The data are presented as the means ± SD. *P < 0.01 Student’s t-test.