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. 2017 Jun 28;11:187. doi: 10.3389/fncel.2017.00187

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Copyright © 2017 Carbone, Costa, Provensi, Mannaioni and Masi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Low intracellular ATP causes a negative shift in Ih activation curve. Top, example of voltage clamp recordings at 1 min (black) and 30 min (red) after patch rupture with control pipette solution. Respective Ih activation curves show perfect overlap (right). Bottom, same experiment, but using a pipette solution with 0 mM ATP and 10 μM oligomycin. Ih activation curve at 30 min is left-shifted by ~9 mV (right). Arrows indicate current traces obtained at the −85 mV test potential to highlight the shift in voltage dependence.