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. 2017 Jun 28;11:187. doi: 10.3389/fncel.2017.00187

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Copyright © 2017 Carbone, Costa, Provensi, Mannaioni and Masi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Local pharmacological Ih suppression causes preferential SNpc DAergic degeneration and hemiparkinsonism. Spontaneous locomotion (A) and apomorphine-induced rotations (B) in rats after repeated monolateral infusions of ZD7288 and Ivabradine (1/day × 4 days). (C) Representative microphotographs showing tyrosine hydroxylase (TH) immunofluorescent labeling on midbrain coronal sections. Circles indicate histologically-confirmed injection sites (scale bar = 1 mm). (D,E) Densitometric analysis of ZD7288- and Ivabradine-induced DAergic degeneration in the SNpc and VTA.