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. 2017 Jun 28;11:176. doi: 10.3389/fncel.2017.00176

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Copyright © 2017 Hansen, Duellberg, Mieck, Loose and Hippenmeyer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Molecular signaling pathways controlling neuronal polarization. (A) A simplified illustration of the biochemical network of axon determination. Only interactions localized to the nascent axon are shown. (B) Positive feedback loops in the process of axon determination. (C) Probing PIP₃ localization and accumulation in polarizing neurons with Akt-pleckstrin-homology (PH)-GFP as a probe for PIP₃.