Table 2.
Direct pair-wise comparison results of obstructive sleep apnea.
| Outcomes | IC versus CPAP |
CPAP versus APAP |
CPAP versus OA |
IC versus OA |
||||
|---|---|---|---|---|---|---|---|---|
| WMD (95% CI) | I2 (%) | WMD (95% CI) | I2 (%) | WMD (95% CI) | I2 (%) | WMD (95% CI) | I2 (%) | |
| AHI | 23.82 (18.49, 29.15) | 93.2 | 0.10 (−3.15, 3.34) | 0.0 | −8.77 (−16.05, −1.50) | 96.2 | 9.40 (5.57, 13.23) | 32.7 |
| ESS | 2.07 (1.51, 2.62) | 88.0 | 0.08 (−0.68, 0.85) | 12.7 | −0.31 (−1.02, 0.39) | 0.0 | 1.15 (0.43, 1.87) | 0.0 |
| AI | 10.76 (7.84, 13.69) | 14.9 | 0.32 (−3.05, 3.69) | 0.0 | −2.59 (−4.91, −0.27) | 0.0 | 9.16 (2.70, 15.61) | 78.9 |
| SaO2 | −9.35 (−11.41, −7.29) | 56.8 | 2.71 (−0.88, 6.29) | 0.0 | 4.91 (2.85, 6.97) | 60.0 | −2.57 (−3.53, −1.61) | 0.0 |
| 24 h SBP | 1.89 (0.86, 2.92) | 23.3 | – | – | −9.57 (−11.34, −7.81) | 0.0 | 1.64 (0.02, 3.26) | 0.0 |
| 24 h DBP | 1.70 (1.13, 2.27) | 0.0 | – | – | −7.11 (−8.06, −6.15) | 0.0 | 1.18 (−0.02, 2.38) | 0.0 |
| dSBP | 3.09 (2.18, 4.01) | 6.8 | −1.70 (−5.11, 1.71) | – | −7.87 (−13.28, −2.46) | 56.5 | 2.81 (−0.13, 5.74) | 0.0 |
| dDBP | 1.98 (1.25, 2.70) | 14.4 | −1.30 (−3.47, 0.87) | – | −2.40 (−8.01, 3.26) | – | 2.15 (0.02, 4.28) | 0.0 |
| nSBP | 4.22 (2.14, 6.30) | 68.0 | −1.10 (−4.74, 2.54) | – | −3.90 (−12.88, 5.08) | – | 1.06 (−2.09, 4.21) | 0.0 |
| nDBP | 1.97 (0.81, 3.13) | 45.9 | −1.30 (−3.42, 0.82) | – | −2.10 (−7.80, 3.60) | – | 0.95 (−1.23, 3.14) | 0.0 |
Treatment: CPAP, continuous positive airway pressure; APAP, auto-adjusting positive airway pressure; IC, inactive control; OA, oral appliance.
Outcomes: AHI, Apnea–Hypopnea Index; ESS, Epworth Sleepiness Scale; SaO2, arterial oxygen saturation; AI, arousal index; SBP, systolic blood pressure; DBP, diastolic blood pressure; d, daytime; n, nighttime; WMD, weighted mean difference; CI, confidence interval.