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. 2017 Jun 28;8:415. doi: 10.3389/fphar.2017.00415

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Copyright © 2017 Valiati, Vasconcelos, Lichtenfels, Petry, de Almeida, Schwartsmann, Schröder, de Farias and Roesler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Amygdalar HDAC inhibition delays IA memory extinction. Rats were given a single IA training trial and tested for retention 24 h later (Test 1). This first test trial also served as extinction training. An infusion of VEH or TSA (22 mM) was given into the BLA immediately after Test 1. Retention was tested once daily from days 1 to 5 after Test 1 (Tests 2–5). A mild reminder footshock was given after Test 5 and rats were tested again 1 day later (Reminder). Data are mean ± SEM latencies to step down; VEH, N = 11, TSA, N = 12; ^∗p < 0.05; ^∗∗p < 0.01 compared to controls.