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HDAC inhibition in the BLA results in increased BDNF levels in the dorsal hippocampus in rats given IA training. Rats were given a bilateral intra-BLA infusion of VEH or TSA (22 mM) immediately after IA training. Four hours later, they were sacrificed and the BLA and dorsal hippocampus levels were removed for BDNF measured with an ELISA. Data are mean ± SEM pg of BDNF/ml of protein; VEH, N = 12, TSA, N = 10; ∗∗p < 0.01 compared to respective controls.
