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. 2017 Jun 28;10:205. doi: 10.3389/fnmol.2017.00205

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Copyright © 2017 Huang, Lu, Li, Cao and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Attenuated acute itch in Tlx3cko mice. The acute itch responses evoked by distinct pruritogens were examined in both Tlx3cko and control mice (A–D). (A) Decreased scratch bouts evoked by Compound48/80 (20 μg) in Tlx3cko mice (control, 145 ± 9, n = 6; Tlx3cko, 48 ± 7, n = 6; p < 0.0001). (B) Decreased scratch bouts evoked by Chloroquine (200 μg) in Tlx3cko mice (control, 120 ± 20, n = 10; Tlx3cko, 24 ± 9, n = 6; p = 0.0037). (C) Decreased scratch bouts evoked by α-Me-5-HT (30 μg) in Tlx3cko mice (control, 138 ± 6, n = 6; Tlx3cko, 42 ± 13, n = 6; p = 0.0002). (D) Decreased scratch bouts evoked by SLIGRL-NH₂ (100 nmol) in Tlx3cko mice (control, 76 ± 11, n = 6; Tlx3cko, 17 ± 3, n = 7; p = 0.0003). **, ***Indicate p < 0.01, p < 0.001, respectively.