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. 2017 Jun 28;8:1145. doi: 10.3389/fmicb.2017.01145

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Copyright © 2017 Som, Heine, Holmes, Munnoch, Chandra, Seipke, Hoskisson, Wilkinson and Hutchings.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activating chloramphenicol production using TB- and Sv-MtrA expression constructs. (Top) Modeling S. venezuelae MtrA (Sv-MtrA) on the published Mycobacterium tuberculosis MtrA (TB-MtrA) structure (Friedland et al., 2007) suggests they are likely to be highly similar. (Bottom) Expression of TB-MtrA and the gain of function Y102C TB-MtrA proteins in wild-type S. venezuelae NRRL B-65442 switches on high level production of chloramphenicol. The equivalent Y99C change in Sv-MtrA has a smaller effect on chloramphenicol production.