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. 2017 Jun 28;8:1206. doi: 10.3389/fmicb.2017.01206

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Copyright © 2017 Zanni, Schifano, Motta, Sciubba, Palleschi, Mauri, Perozzi, Uccelletti, Devirgiliis and Miccheli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of production and consumption of metabolites, expressed by net balances. (A) Principal components analysis (PCA) score plot relative to L. delbrueckii 23 (green circles), L. delbrueckii bulgaricus (red squares) and L. delbrueckii lactis (blue triangles). Eighty percent of total variability represented in two components (PC1: 65%; PC2: 15%). (B) PCA loadings plot indicating statistically significant differences of excreted or consumed metabolites between the two L. delbrueckii 23 and L. delbrueckii lactis with respect to L. delbrueckii bulgaricus along PC1, or between both L. delbrueckii lactis subspecies and L. delbrueckii bulgaricus along PC2.