Table 5.
Effect of oral administration of EtOHE-Me and loperamide on castor oil induced-diarrhea in mice
| Treatment, as p.o. | Dose in mg/kg | Evacuation index | Wet feces | Inhibition of diarrhea |
| NaCl 0.9% | - | 21 (19-25) | 47% | - |
| Loperamide | 5 | 0 (0-4)2 | 0% | 100% |
| EtOHE-Me | 62.5 | 8 (5-11)1 | 4% | 62% |
| 125 | 7 (6-8)1 | 2% | 66% | |
| 250 | 6.5 (3-7)1 | 0% | 69% | |
| 500 | 4 (3-5)13 | 0% | 81% |
1
Significant differences between treated groups vs NaCl 0.9% control group (P < 0.05);
2
Significant differences between loperamide group vs NaCl 0.9% control group (P < 0.001);
3
Significant differences between EtOHE-Me 250 mg/kg vs EtOHE-Me 500 mg/kg (P < 0.05). Data are expressed as median (minimum-maximum). EtOHE-Me: Ethanol extract of Maytenus erythroxylon.