Figure 3.

Models of transcriptional regulation

In the bridging scaffold model (A), activating RNAs (red line) are transcribed from enhancer-like non-coding genes and are required to recruit the mediator complex and to mediate chromatin conformational changes bridging the enhancer-like non-coding gene and the promoter of a coding gene. In the tethered scaffold model (B), lncRNA (red line) recognises specific DNA motifs and recruits histone modifying enzymes such as PRC2 to the locus. lncRNA, long non-coding RNA; PRC2, polycomb repressive complex 2; RNAPII, RNA polymerase II.