FIG 8.

Neutralization of hVLPs by a panel of bnAbs. Results are shown for a comparison of neutralization sensitivities to bnAbs between V1 and V4 VLPs (A) as well as between V1 and standard pseudovirions generated in 293T cells (293T VLPs) (B). The estimated fold change in the IC₅₀ between 293T VLPs and V4 VLPs shown in panel B (*) was calculated using IC₅₀s from two independent experiments, both of which included V1 VLPs, as follows: fold change in IC₅₀ = (IC₅₀ 293T VLPs/IC₅₀ V1 VLPs_{experiment B})/(IC₅₀ V4 VLPs/IC₅₀ V1 VLPs_{experiment A}). na, not applicable (the fold change in IC₅₀ could not be calculated because the antibodies did not reach an IC₅₀ at the highest or lowest concentration tested); sCD4, soluble CD4.