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Relationship between gp120-specific B cells and T follicular helper cells. (A) No significant correlation between HIV gp120-specific memory B cell subsets and CXCR5+ CD4+ T cells. (B) Several diametric associations between Env-specific IL-21+ CXCR5+ CD4+ T cells and HIV gp120-specific memory B cell subsets. Orange squares represent HIV progressors; blue circles and green triangles represent HIV VC and HIV EC, respectively. Correlation was analyzed by the Spearman correlation test.
