Fig. 5.

Absence of SUCNR1 improves glucose tolerance on HFD feeding. Sucnr1 ^−/− and WT mice were subjected to LFD or HFD feeding for 16 weeks (n = 7). (a) Plasma glucose and (b) insulin levels, 4 h fasted after 16 weeks of HFD feeding. Blood glucose levels and AUC during GTTs, overnight fasted after 2 weeks (c, d), 8 weeks (e, f) and 16 weeks (g, h) of LFD or HFD feeding. White/grey, WT; black, Sucnr1 ^−/−; squares, LFD; circles, HFD. ^* p < 0.05, ^** p < 0.01 and ^*** p < 0.001