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Single-dose plasma pharmacokinetics of eravacycline. Six different doses that varied by a 2-fold concentration on a milligram-per-kilogram basis were administered to mice by the i.p. route. Groups of three mice were sampled for each time point. Each symbol represents the mean ± SD for three animals. Shown in the legend is the maximum plasma concentration (Cmax), the area under the concentration-time curve from time zero to infinity (AUC0–∞), and the elimination half-life (t1/2).
