FIG 2.

In vivo dose fractionation with eravacycline using a neutropenic murine thigh infection model. Each symbol represents the mean and standard deviation for four thighs infected with E. coli ATCC 25922. The error bars represent the standard deviations. The burden of organisms was measured at the start and end of therapy. Five total drug dose levels (in milligrams per kilogram every 24 h) were fractionated into one of four dosing regimens and are shown on the x axis. The y axis represents the change in organism burden from the start of therapy. The dashed horizontal line represents net stasis over the treatment period. Points above the line represent net growth, and points below the line represent net killing (cidal activity). Q 6h, Q 8h, Q 12h, and Q 24h, dosing every 6, 8, 12, and 24 h, respectively.