FIG 4.

In vivo dose-effect of eravacycline against six E. coli (EC) strains using a neutropenic murine thigh infection model. Each symbol represents the mean and standard deviation for four thighs. Five total drug dose levels were fractionated into a regimen given every 12 h. The burden of organisms was measured at the start and end of therapy. The study period was 24 h. The horizontal dashed line at 0 represents the burden of organisms in the thighs of mice at the start of therapy. Data points below the line represent killing, and points above the line represent growth.