FIG 5.
In vivo dose-effect of eravacycline against six E. coli isolates using a neutropenic murine thigh infection model. Eravacycline exposure is expressed as the free drug 24-h AUC/MIC (fAUC/MIC). R2 represents the coefficient of determination. The ED50 represents the AUC/MIC associated with 50% of the maximal effect (Emax), and N is the slope of the relationship, or the Hill coefficient. The line drawn through the data points is the best-fit line based upon the sigmoid Emax formula. The dashed line represents the burden at the start of therapy. Points above the line represent net growth, and those below the line represent killing.