FIG 2.

Nonhuman primate study timelines and biological sample collection points for the PK1 dose-ranging study (n = 5 per dosage group, 3 groups) (a) and the PK2 study (n = 4) (b). Arrows with circles, times of cervicovaginal fluid (CVF) collection using Tear-Flo strips (proximal to the IVR [black], proximal and distal to the IVR [gray]); black arrows, CVL fluid and serum collection (*, only CVL fluid collection); gray arrows, collection of pH and swab samples for determination of the Nugent score. Note 1, vaginal fluid samples in PK2 phase A were collected at 1 h, 4 h, 24 h, 48 h, 72 h, and 168 h (7 days). d, days.