TABLE 2.
In vitro test of the growth-inhibitory effects of predicted inhibitors on L. donovani promastigotes and amastigotesa
| Compound | IC50 value (μM) |
|
|---|---|---|
| In vitro | Ex vivo | |
| ASN13153257 | 14 | 26 |
| AOP22837786 | 28 | 45 |
| ZINC02126235 | 38 | 60 |
| ASN14391226 | 62 | 85 |
| ASN08253385 | 78 | 90 |
| ASN16457210 | 42 | 56 |
| Miltefosine (positive control) | 1.0 | 1.5 |
a
Shown are the results of in vitro testing of the growth-inhibitory effects of the predicted inhibitors on L. donovani promastigotes (MTT assay) and amastigotes (Giemsa staining) as determined with miltefosine as a positive control.