TABLE 1.
Parameter estimates in the final VCZ population PK modela
| Parameter | Estimate | RSE (%) | Interindividual variability | RSE (%) |
|---|---|---|---|---|
| V1 pop (liters) | 0.241 | 10 | ||
| V2_healthy (liters) | 0.352 | 12 | 0.258 | 21 |
| V2_infected (liters) | 0.216 | 12 | 0.258 | 21 |
| β_V2_infected | −0.487 | 32 | NA | NA |
| k12 pop (h−1) | 8.530 | 22 | 0.458 | 21 |
| k21 pop (h−1) | 6.130 | 8 | ||
| VM_healthy (μg/ml) | 0.324 | 13 | 0.312 | 21 |
| VM_infected (μg/ml) | 0.186 | 15 | 0.312 | 21 |
| β_VM_infected | −0.557 | 34 | NA | NA |
| kM (μg/ml) | 0.540 | |||
| Residual variability | ||||
| Proportional, plasma | 0.118 | 8 | NA | NA |
| Combined, brain | ||||
| Additive | 0.025 | 28 | NA | NA |
| Proportional | 0.041 | 27 | NA | NA |
| Log-likelihood estimation | ||||
| AIC | −383.29 | NA | NA | NA |
a
NA, not applicable; RSE, relative standard error (standard error of estimate/estimate × 100).