TABLE 1.

The change in log₁₀ CFU per milliliter at 4, 24, and 48 h during time-kill experiments with monotherapy with polymyxin B or minocycline against an inoculum of ∼10⁶ CFU/ml of KPC-producing K. pneumoniae clinical isolates^a

Clinical isolate	Time (h)	Change in log10 no. of CFU/ml with:
		Control	PMB (mg/liter)					MIN (mg/liter)
			0.5	1	2	4	16	1	2	4	8	16
BRKP62	4	1.97	−3.32	−4.58	−4.84	−6.11	−6.25	2.19	1.41	−0.12	−0.15	−0.30
	24	2.81	2.90	2.61	2.74	2.51	−3.04	3.27	3.03	2.48	2.38	1.06
	48	2.95	3.09	2.90	3.10	3.07	2.06	3.20	3.37	3.18	3.11	3.14
BRKP07	4	2.12	−3.49	−2.77	−2.70	−2.60	−6.01	1.71	−0.18	−0.79	−0.66	−0.55
	24	2.98	3.00	3.08	3.06	2.97	2.20	2.88	2.90	2.78	2.70	1.38
	48	3.21	3.16	3.21	3.32	3.21	3.19	2.77	2.91	2.84	2.79	2.91
BRKP21	4	2.35	−3.48	−3.44	−3.66	−6.21	−6.00	2.29	0.70	0.30	−0.06	−0.87
	24	2.97	3.03	2.71	2.83	2.89	−1.20	3.00	3.04	2.91	2.91	2.69
	48	2.97	3.24	2.88	2.89	3.05	3.12	2.95	3.04	2.86	3.12	3.19
BRKP25	4	2.42	−4.00	−4.26	−4.18	−4.62	−5.87	2.55	2.34	0.80	−0.01	−0.20
	24	3.05	3.15	3.07	1.27	2.91	−4.09	3.07	2.24	2.14	2.26	0.10
	48	3.08	3.28	3.48	3.32	3.41	2.09	3.21	2.73	2.56	2.58	2.73
BRKP27	4	1.93	−3.07	−1.99	−2.29	−2.56	−4.49	1.17	1.27	−0.78	−0.78	−1.34
	24	2.62	2.83	2.76	2.00	2.47	2.89	3.07	2.91	2.77	2.99	2.75
	48	2.69	2.65	2.89	2.62	2.29	2.61	2.99	3.00	2.99	3.05	2.55
BRKP57	4	2.07	1.44	1.52	1.13	0.59	−0.48	1.74	0.83	0.50	0.00	−0.35
	24	3.05	2.98	3.09	3.16	3.09	3.15	3.02	2.54	2.64	2.11	−0.34
	48	3.31	3.16	3.20	3.40	3.37	3.19	3.15	2.73	3.06	2.97	2.59

^aBactericidal activity (≥3 log₁₀ CFU/ml reduction compared to the initial inoculum) is shown in bold. PMB, polymyxin B; MIN, minocycline.