TABLE 2.
Parameter value estimates for the base model stage 1a
| Parameter | Typical value | %RSE | 95% CI |
|---|---|---|---|
| CL/F (liters/h) | 19.5 | 3.9 | 18.2–20.8 |
| V/F (liters) | 27.1 | 13.9 | 20.9–33.3 |
| Ka (h−1) | 0.277 | 9.8 | 0.23–0.32 |
| NN | 1.5 | 41 | 0.09–3.9 |
| MMT (h) | 0.326 | 35 | 0.05–1.0 |
| Random effects | |||
| IIVCL | 0.165 | 15.3 | 0.12–0.20 |
| IIVV | 0.425 | 27.1 | 0.25–0.59 |
| IIVMMT | 0.0706 | 75 | 0.01–1.79 |
| Residual variability | |||
| Proportional error (%) | 0.23 | 7.8 | 0.20–0.26 |
a
CL/F, clearance (F is unknown bioavailability); V/F apparent volume of distribution; Ka, absorption rate constant; NN, number of transit compartment; MMT, absorption mean transit time; IIVCL, interindividual variability on clearance; IIVV, interindividual variability on volume; IIVMMT, interindividual variability on absorption mean transit time. RSE, relative standard error reported. CI, confidence interval.