TABLE 3.
Parameter value estimates for the final model stage 2a
| Parameter | Typical value (shrinkage [%]) | %RSE | 95% CI |
|---|---|---|---|
| CL/F (liters/h) | 19.6 | 12 | 16.7–22.5 |
| V/F (liters) | 23.6 | 9 | 17.1–30.1 |
| Ka (h−1) | 0.277 (FIX) | ||
| NN | 1.5 (FIX) | ||
| MMT (h) | 0.326 (FIX) | ||
| THETA_sexmale | 1.2 | 13 | 1.0–1.3 |
| Random effects | |||
| IIVCL | 0.076 (22) | 29 | 0.033–0.11 |
| IIVV | 0.397 (28) | 29 | 0.17–0.63 |
| IIVMMT | 0.0706 (FIX) | ||
| Residual variability | |||
| Proportional error (%) | 0.22 | 12 | 0.19–0.26 |
a
CL/F, clearance (F is unknown bioavailability); V/F apparent volume of distribution; FIX, value was fixed after model stage 1; NN, number of transit compartment; MMT, absorption mean transit time; THETA_sexmale, fractional change in clearance for males; IIVCL, interindividual variability on clearance; IIVV, interindividual variability on volume; IIVMMT, interindividual variability on absorption mean transit time. RSE, relative standard error reported. CI, confidence interval.