TABLE 2.

Pharmacokinetic parameters following a single intramuscular administration of ceftaroline in rats

Parametera	Value (±SD)
	20 mg/kg	40 mg/kg
ke (h−1)	2.42 ± 0.17	1.96 ± 0.18
ka (h−1)	2.52 ± 0.202	2.18 ± 0.22
Cmax (mg/liter)	28.6 ± 4.02	48.50 ± 4.06
t1/2 (h)	0.287 ± 0.211	0.356 ± 0.035
V (liter/kg)	0.269 ± 0.039	0.321 ± 0.024
AUC0–∞ (mg · h/liter)	30.89 ± 2.23	63.91 ± 2.13

^ak_e, elimination rate constant; k_a, absorption rate constant; t_1/2, elimination half-life; V, volume of distribution; AUC_0–∞, area under the concentration-time curve from 0 h to infinity.