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. 2017 Jun 27;61(7):e00363-17. doi: 10.1128/AAC.00363-17

TABLE 2.

Activity of elbasvir in GT4 subtypes

Replicon (GenBank accession no.)^a	Mean EC (nM) ± SD^b
Replicon (GenBank accession no.)^a	EC₅₀	EC₉₀
GT4a (GU814265)	0.0002 ± 0.0001	0.0008 ± 0.0001
GT4a (DQ418784)	0.0002 ± 0.0001	0.0005 ± 0.0002
GT4b (FJ025854)	0.017 ± 0.017	0.030 ± 0.016
GT4b (FJ025855)	34 ± 23	>100
GT4b (FJ462435)	3.6 ± 2.3	6.2 ± 3.8
GT4d (DQ418786)	0.0005 ± 0.0001	0.003 ± 0.001
GT4d (EU392172)	0.0004 ± 0.0001	0.0011 ± 0.0002
GT4f (EF589161)	0.0019 ± 0.0014	0.018 ± 0.028
GT4g (JX227963)	0.0006 ± 0.0002	0.0017 ± 0.001
GT4g (JX227971)	0.072 ± 0.035	0.25 ± 0.13
GT4m (FJ462433)	0.0004 ± 0.0001	0.0024 ± 0.0016
GT4m (JX227972)	0.0007 ± 0.0005	0.0043 ± 0.0024
GT4o (JX227977)	0.0022 ± 0.001	0.016 ± 0.011
GT4q (FJ462434)	0.0005 ± 0.0001	0.0014 ± 0.0003

^a

All replicons have the GT4a NS5A sequences in a JFH1 background.

^b

Averages of ≥3 analyses are shown.