Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
De novo resistance selections with grazoprevir in the GT4a replicon
| Grazoprevir concn (nM) | Treatment (fold EC50) | Mutations (% population)a |
|---|---|---|
| No drug | 0 | A61T (100), G90R (5) |
| 1 | 1 | A61T (100), G90R (5) |
| 3 | 3 | A61T (100), G90R (5), G162R (5) |
| 10 | 10 | A61T (70), G90R (5), D168V (30), D168G (30) |
| 30 | 30 | A61T (95), G90R (5), D168V (50), D168A (50) |
Key amino acid substitutions deduced from population sequencing of resistant colonies and quantified based on peaks from the electropherogram are indicated.
