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De novo resistance selections with elbasvir in the GT4a (ED43) replicon
| Treatment (fold multiple of EC90) | No. of resistant coloniesa | Activity (EC90 [nM]) in pooled colonies | Fold shift (relative to DMSO) | Substitution(s) observedb |
|---|---|---|---|---|
| 3 | TMTCa | 0.003 | 6 | L30F, M31V, Y93H |
| 10 | 144 | 0.017 | 34 | L30F, L30P, M31V, N69K, Y93H |
| 30 | 35 | 0.02 | 40 | L30S |
TMTC, too many to count.
Key amino acid substitutions deduced from population sequencing of resistant colonies are listed.
