TABLE 7.
Global prevalence of polymorphisms within NS3 in HCV GT4 population
| Parameter | Amino acid position |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 36 | 54 | 55 | 56 | 80 | 107 | 122 | 132 | 155 | 156 | 158 | 168 | 170 | 175 | |
| GT4 ED43 | L | T | V | Y | Q | V | T | I | R | A | V | D | V | L |
| GT4 conservation (%)a | 100 | 97.3 | 99.5 | 100 | 99.5 | 95.9 | 93.6 | 96.8 | 100 | 100 | 99.5 | 99.5 | 93.6 | 100 |
| GT4 substitutionb | L | T | V | Y | Q | V | T/S | I | R | A | V | D | V/I | L |
| No. of database sequences evaluated | 219 | 218 | 219 | 219 | 219 | 219 | 218 | 219 | 196 | 196 | 195 | 187 | 188 | 188 |
a
That is, the percent conservation of the reference sequence.
b
That is, the substitution within the specified positions that has ≥5% of the sequences in the database. Substitutions are presented in order of decreasing frequency.