TABLE 2.

Dose reduction strategies following inhibition of factors involved in drug absorption of TDF^a

Inhibited factor(s)	Dose size (mg)	AUC0–24 (ng · h ml−1)	% difference from control
None (control)	300	3,036	NA
ABCB1	200	2,897	−5
ABCB1 + CES	150	3,002	−1
Lipase	90	3,337	10
ABCB1 + lipase	60	3,279	8
ABCB1 + CES + lipase	50	3,133	3

^aParameters were determined following 6 days of once-daily oral dosing of TDF in 100 healthy male subjects. NA, not applicable.