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Physiological factors relevant for simulating the oral absorption of TFV disoproxil and TFV in the PBPK model
| Segment | pH | Vol (ml) | Radius (cm) | Transit time (h) | Absorption scaling |
|---|---|---|---|---|---|
| Stomach | 1.3 | 46.56 | NAa | 0.25 | ×0 |
| Duodenum | 6 | 41.56 | 1.53 | 0.26 | ×1 |
| Jejunum 1 | 6.2 | 154.2 | 1.45 | 0.93 | ×1 |
| Jejunum 2 | 6.4 | 122.3 | 1.29 | 0.74 | ×1 |
| Ileum 1 | 6.6 | 94.29 | 1.13 | 0.58 | ×1 |
| Ileum 2 | 6.9 | 70.53 | 0.98 | 0.42 | ×1 |
| Ileum 3 | 7.4 | 49.83 | 0.82 | 0.29 | ×1 |
| Cecum | 6.4 | 47.49 | 3.39 | 4.19 | ×1 |
| Colon | 6.8 | 50.33 | 2.41 | 12.57 | ×0.1 |
NA, not applicable.
