FIG 2.

Effect of pH on the efficacy of ciprofloxacin and finafloxacin against B. pseudomallei strains over a 24-h period. Time-kill assays were performed in L broth adjusted to pH 5 or pH 7 with finafloxacin (16 μg/ml) or ciprofloxacin (4 μg/ml). An untreated bacterial control was included. (A) Ciprofloxacin against B. pseudomallei strain K96243. (B) Ciprofloxacin against B. pseudomallei strain 576. (C) Finafloxacin against B. pseudomallei strain K96243. (D) Finafloxacin against B. pseudomallei strain 576. The error bars represent the standard errors of the mean (SEMs) from 3 biological replicates. ┈, 3-log₁₀ reduction in CFU/ml from the starting inoculum.