FIG 6.

A fragment of multiple-sequence alignment showing the conservation of His374 (A. fumigatus CYP51B numbering) in fungal CYP51 enzymes. Human and Zea mays CYP51 sequences are included for the comparison with fungal CYP51 enzyme sequences. The type B (versus type A) CYP51-defining proline is shadowed in gray. The sequences were aligned using the Clustal Omega program, and the figure was prepared in the GeneDoc program. Z. mays, Zea mays; V.nashicol, Venturia nashicola; U.necator, Uncinula necator; B.graminis, Blumeria graminis; M.acuformi, Melanella acuformis; A.fumigatB, Aspergillus fumigatus B; A.flavusB, Aspergillus flavus B; A.clavatB, Aspergillus clavatus B; A.terreusB, Aspergillus terreus B; C.posadasi, Coccidioides posadasii; C.immitis, Coccidioides immitis; F.nodorum, Fusarium nodorum; M.graminic, Mycosphaerella graminicola; P.italicum, Penicillium italicum; A.fumigatA, Aspergillus fumigatus A; A.clavatA, Aspergillus clavatus A; A.flavusA, Aspergillus flavus A; A.terreusA, Aspergillus terreus A; C.albicans, Candida albicans; C.dublinie, Candida dubliniensis; C.tropical, Candida tropicalis; C.krusei, Candida krusei; C.glabrata, Candida glabrata; C.neoforma, Cryptococcus neoformans; M.globosa, Malassezia globosa.