FIG 1.

Competitive fitness of matched pairs of fluconazole-resistant isolates (dark gray bars) and fluconazole-susceptible isolates (light gray bars) from the same patients. In each case, the susceptible isolate was mixed with two independently generated RFP-labeled derivatives of the matched resistant isolate and the resistant isolate was mixed with two independently generated RFP-labeled derivatives of the matched susceptible isolate. Shown are the relative proportions of the two strains in the inoculum (day 0) and after two rounds of coculture (day 1 and day 2) at 30°C in YPD medium. Results are the means and standard deviations for the four cocultures. For isolate pair F2/F5, each combination was tested four times; i.e., results are from 16 cocultures. Significant differences in the proportions of the resistant isolates at day 1 and day 2 compared to day 0 are indicated by asterisks (P < 0.05). See Data Set S1 for details.