TABLE 1.
Levels of hepatic and renal biomarkers in serum samples from healthy rabbits, Vibrio cholerae-infected rabbits, and infected rabbits treated with entinostata
| Rabbit group (n) | Levels of hepatic enzymes (U/liter) |
Levels of renal markers |
|||
|---|---|---|---|---|---|
| ALT | AST | GGT | Creatinine (μmol/liter) | BUN (mmol/liter) | |
| Healthy (5) | 55.9 ± 6.2 | 66.8 ± 14.4 | 10.6 ± 1.0 | 105.6 ± 11.9 | 4.08 ± 1.0 |
| Infected and not treated (4) | 62.02 ± 16.2 | 30.69 ± 6.1 | 10.1 ± 3.2 | 70.83 ± 16.3 | 17.05 ± 5.8 |
| Infected and treated with entinostat | |||||
| 0.5 mg b.d.s. for 2 days (5) | 39.91 ± 11.4 | 30.18 ± 6.6 | 11.25 ± 2.8 | 63.42 ± 12.5 | 19.3 ± 6.9 |
| 1 mg q.d. for 2 days (5) | 49.78 ± 8.2 | 41.6 ± 14.8 | 6.4 ± 1.2 | 77.82 ± 2.3 | 8.2 ± 1.4 |
a
Data are expressed as means ± SEM. ALT, alanine transaminase; AST, aspartate transaminase; GGT, gamma-glutamyl transferase; BUN, blood urea nitrogen; b.d.s., twice daily; q.d., once a day.