TABLE 5.
Effects of Pma1 inhibitors on medium acidification in S. cerevisiae and C. albicansa
| Compound | IC50 (μM) for acidification |
|
|---|---|---|
| S. cerevisiae | C. albicans | |
| 14 | 11.2 ± 2.7 | 6.6 ± 2.5 |
| 15 | 1.7 ± 0.1 | 1.6 ± 0.0 |
| 16 | 7.6 ± 3.4 | 3.4 ± 1.6 |
| 17 | 39.6 ± 10.3 | 19.1 ± 1.7 |
| 18 | 12.5 ± 1.1 | 8.8 ± 0.4 |
| 19 | 2.3 ± 0.1 | 2.3 ± 0.5 |
| BM2 | 0.2 ± 0.0 | 0.5 ± 0.1 |
| Vanadate | >40 | >40 |
| Ebselen | 7.6 ± 0.0 | 9.4 ± 2.1 |
| AMB | >75 | >75 |
a
The IC50 was determined to be the concentration which resulted in 50% inhibition of medium acidification normalized to the response from glucose-activated versus non-glucose-activated cells. AMB, amphotericin B. IC50 with standard deviations (n = 2 to 3) are indicated.