Table 4.
Frequency of total B cells follicles and the percentage containing germinal centres
| Donor group | B cell follicle frequency, per mm2 (median) | Germinal centre frequency, % of total (median) |
|---|---|---|
| Non-diabetic controla | 1.83 ± 0.22 (1.77) | 21.91 ± 5.6 (14.3) |
| Autoantibody-positive | 2.59 ± 0.42 (2.4) | 6.66 ± 2.14 (7.84) |
| T1D | ||
| RO | 1.99 ± 0.36 (1.55) | 4.99 ± 2.1 (0.0) |
| LD | 1.87 ± 0.28 (1.64) | 10.85 ± 3.8 (8.64) |
| T1D with insulitis | 9.22 ± 2.68 (7.7) | |
| RO | 2.1 ± 0.37 (1.62) | 5.4 ± 2.2 (0.0) |
| LD | 1.95 ± 0.34 (1.72) | 13.78 ± 5.02 (10.32) |
| RO T1D | ||
| Dx <15 years | 1.61 ± 0.39 (1.37) | 5.56 ± 3.64 (0.0) |
| Dx ≥15 years | 2.43 ± 0.63 (1.86) | 4.35 ± 2.06 (2.94) |
Data are means ± SEM
aNon-diabetic control group results remained consistent throughout the analysis and are therefore described only once
Dx, diagnosis; LD, longer duration; RO, recent onset; T1D, type 1 diabetes