Table 3.
Univariate analysis of gene variables for DMFS according to molecular subtype
| All | HR+/HER2− | HR+/HER2+ | HR−/HER2+ | TNBC | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hazard ratio | 95% CI | P value | Hazard ratio | 95% CI | P value | Hazard ratio | 95% CI | P value | Hazard ratio | 95% CI | P value | Hazard ratio | 95% CI | P value | ||||||
| No. of patients (no. of events) | 815 (209) | 408 (108) | 111 (32) | 104 (28) | 192 (41) | |||||||||||||||
| p-genes | ||||||||||||||||||||
| AURKA | 1.07 | 0.99 | 1.15 | 0.086 | 1.16 | 1.04 | 1.29 | 0.006 | 1.02 | 0.84 | 1.24 | 0.806 | 1.21 | 0.99 | 1.47 | 0.067 | 0.88 | 0.75 | 1.04 | 0.140 |
| CCNB2 | 1.12 | 0.98 | 1.28 | 0.096 | 1.32 | 1.09 | 1.60 | 0.005 | 1.07 | 0.76 | 1.50 | 0.710 | 0.99 | 0.64 | 1.54 | 0.976 | 0.93 | 0.64 | 1.35 | 0.697 |
| FOXM1 | 1.17 | 1.03 | 1.33 | 0.015 | 1.37 | 1.14 | 1.65 | 0.001 | 1.24 | 0.83 | 1.85 | 0.294 | 1.04 | 0.61 | 1.75 | 0.898 | 1.05 | 0.75 | 1.47 | 0.763 |
| MKI67 | 1.19 | 1.03 | 1.38 | 0.017 | 1.36 | 1.11 | 1.66 | 0.002 | 1.22 | 0.86 | 1.73 | 0.270 | 1.12 | 0.76 | 1.64 | 0.578 | 0.95 | 0.65 | 1.38 | 0.772 |
| MMP11 | 1.27 | 1.15 | 1.40 | <0.001 | 1.22 | 1.06 | 1.39 | 0.004 | 1.39 | 1.07 | 1.80 | 0.012 | 1.57 | 1.16 | 2.13 | 0.003 | 1.16 | 0.92 | 1.46 | 0.208 |
| PTTG1 | 1.02 | 0.85 | 1.21 | 0.853 | 1.02 | 0.79 | 1.32 | 0.896 | 1.25 | 0.84 | 1.86 | 0.267 | 0.97 | 0.57 | 1.66 | 0.917 | 0.93 | 0.60 | 1.43 | 0.736 |
| RACGAP1 | 1.14 | 0.99 | 1.32 | 0.078 | 1.24 | 1.02 | 1.51 | 0.028 | 1.27 | 0.82 | 1.96 | 0.282 | 1.10 | 0.71 | 1.71 | 0.677 | 0.94 | 0.66 | 1.35 | 0.751 |
| RRM2 | 1.17 | 1.02 | 1.35 | 0.026 | 1.40 | 1.14 | 1.71 | 0.001 | 1.65 | 1.07 | 2.53 | 0.022 | 0.81 | 0.52 | 1.26 | 0.343 | 0.89 | 0.64 | 1.22 | 0.451 |
| TOP2A | 1.19 | 1.09 | 1.31 | <0.001 | 1.38 | 1.21 | 1.56 | <0.001 | 1.21 | 0.96 | 1.51 | 0.104 | 0.99 | 0.74 | 1.34 | 0.971 | 0.89 | 0.69 | 1.15 | 0.380 |
| UBE2C | 1.23 | 1.09 | 1.39 | 0.001 | 1.44 | 1.21 | 1.71 | <0.001 | 1.43 | 1.01 | 2.04 | 0.046 | 0.69 | 0.45 | 1.07 | 0.096 | 1.17 | 0.88 | 1.55 | 0.277 |
| i-genes | ||||||||||||||||||||
| BTN3A2 | 0.90 | 0.77 | 1.06 | 0.208 | 0.87 | 0.69 | 1.09 | 0.220 | 1.07 | 0.68 | 1.68 | 0.772 | 0.56 | 0.35 | 0.88 | 0.013 | 1.12 | 0.81 | 1.55 | 0.484 |
| CCL19 | 0.98 | 0.89 | 1.09 | 0.730 | 0.99 | 0.86 | 1.14 | 0.860 | 0.89 | 0.68 | 1.17 | 0.403 | 0.91 | 0.70 | 1.18 | 0.465 | 1.12 | 0.89 | 1.40 | 0.345 |
| CD2 | 0.96 | 0.86 | 1.07 | 0.445 | 1.03 | 0.89 | 1.20 | 0.687 | 0.93 | 0.70 | 1.24 | 0.628 | 0.61 | 0.44 | 0.85 | 0.004 | 1.06 | 0.82 | 1.38 | 0.650 |
| CD52 | 0.99 | 0.97 | 1.01 | 0.177 | 0.99 | 0.96 | 1.02 | 0.651 | 0.98 | 0.92 | 1.04 | 0.467 | 0.97 | 0.92 | 1.02 | 0.216 | 0.99 | 0.95 | 1.03 | 0.698 |
| HLADPA1 | 1.00 | 0.89 | 1.12 | 0.973 | 0.95 | 0.81 | 1.11 | 0.502 | 0.93 | 0.69 | 1.26 | 0.658 | 0.89 | 0.68 | 1.18 | 0.426 | 1.28 | 0.98 | 1.67 | 0.075 |
| TRBC1 | 0.93 | 0.79 | 1.09 | 0.356 | 0.91 | 0.72 | 1.15 | 0.439 | 1.01 | 0.65 | 1.57 | 0.960 | 0.67 | 0.45 | 0.99 | 0.043 | 1.15 | 0.83 | 1.60 | 0.403 |
| Lymph node-negative | ||||||||||||||||||||
| No. of patients (no. of events) | 421 (64) | 202 (29) | 45 (7) | 58 (12) | 116 (16) | |||||||||||||||
| p-genes | ||||||||||||||||||||
| AURKA | 1.06 | 0.92 | 1.21 | 0.418 | 1.20 | 0.98 | 1.47 | 0.078 | 1.01 | 0.65 | 1.58 | 0.963 | 1.02 | 0.73 | 1.43 | 0.905 | 0.93 | 0.72 | 1.21 | 0.583 |
| CCNB2 | 1.18 | 0.91 | 1.53 | 0.208 | 1.37 | 0.93 | 2.03 | 0.114 | 1.09 | 0.54 | 2.22 | 0.812 | 0.78 | 0.37 | 1.65 | 0.516 | 1.34 | 0.68 | 2.62 | 0.398 |
| FOXM1 | 1.34 | 1.08 | 1.67 | 0.009 | 1.57 | 1.13 | 2.18 | 0.007 | 2.22 | 0.88 | 5.61 | 0.093 | 1.21 | 0.57 | 2.54 | 0.621 | 1.27 | 0.73 | 2.22 | 0.401 |
| MKI67 | 1.29 | 1.01 | 1.64 | 0.042 | 1.50 | 1.08 | 2.08 | 0.014 | 1.45 | 0.77 | 2.74 | 0.253 | 1.17 | 0.65 | 2.11 | 0.595 | 0.89 | 0.47 | 1.65 | 0.702 |
| MMP11 | 1.26 | 1.06 | 1.50 | 0.008 | 1.21 | 0.95 | 1.56 | 0.124 | 1.98 | 1.11 | 3.54 | 0.021 | 1.56 | 0.98 | 2.50 | 0.063 | 0.99 | 0.69 | 1.42 | 0.957 |
| PTTG1 | 1.28 | 0.93 | 1.77 | 0.127 | 1.38 | 0.86 | 2.23 | 0.185 | 1.34 | 0.62 | 2.91 | 0.455 | 0.92 | 0.41 | 2.06 | 0.837 | 1.49 | 0.74 | 2.98 | 0.265 |
| RACGAP1 | 1.16 | 0.89 | 1.51 | 0.264 | 1.24 | 0.86 | 1.78 | 0.255 | 1.18 | 0.47 | 2.93 | 0.722 | 1.46 | 0.72 | 2.96 | 0.291 | 0.90 | 0.49 | 1.65 | 0.736 |
| RRM2 | 1.35 | 1.04 | 1.75 | 0.025 | 1.74 | 1.18 | 2.57 | 0.006 | 1.43 | 0.51 | 3.95 | 0.495 | 0.92 | 0.46 | 1.84 | 0.809 | 1.06 | 0.62 | 1.82 | 0.839 |
| TOP2A | 1.29 | 1.09 | 1.53 | 0.004 | 1.45 | 1.14 | 1.85 | 0.002 | 1.45 | 0.85 | 2.50 | 0.176 | 1.17 | 0.72 | 1.89 | 0.527 | 1.11 | 0.68 | 1.80 | 0.685 |
| UBE2C | 1.37 | 1.09 | 1.73 | 0.007 | 1.64 | 1.15 | 2.32 | 0.006 | 1.89 | 0.88 | 4.06 | 0.104 | 0.63 | 0.31 | 1.28 | 0.201 | 1.53 | 0.89 | 2.65 | 0.125 |
| i-genes | ||||||||||||||||||||
| BTN3A2 | 0.81 | 0.60 | 1.09 | 0.161 | 0.65 | 0.41 | 1.04 | 0.074 | 1.05 | 0.41 | 2.71 | 0.912 | 0.50 | 0.26 | 0.99 | 0.045 | 1.26 | 0.75 | 2.14 | 0.383 |
| CCL19 | 0.95 | 0.79 | 1.14 | 0.586 | 0.89 | 0.68 | 1.16 | 0.397 | 0.70 | 0.38 | 1.26 | 0.234 | 0.80 | 0.50 | 1.27 | 0.342 | 1.34 | 0.93 | 1.93 | 0.120 |
| CD2 | 0.88 | 0.73 | 1.06 | 0.182 | 0.78 | 0.59 | 1.05 | 0.100 | 0.78 | 0.39 | 1.53 | 0.462 | 0.60 | 0.37 | 0.96 | 0.033 | 1.31 | 0.86 | 2.00 | 0.207 |
| CD52 | 0.99 | 0.95 | 1.03 | 0.593 | 0.98 | 0.92 | 1.05 | 0.640 | 1.00 | 0.90 | 1.12 | 0.986 | 0.96 | 0.87 | 1.05 | 0.352 | 1.01 | 0.95 | 1.07 | 0.798 |
| HLADPA1 | 0.93 | 0.76 | 1.14 | 0.484 | 0.82 | 0.61 | 1.10 | 0.190 | 0.72 | 0.37 | 1.39 | 0.324 | 0.80 | 0.51 | 1.26 | 0.344 | 1.40 | 0.93 | 2.11 | 0.105 |
| TRBC1 | 0.74 | 0.55 | 1.00 | 0.050 | 0.73 | 0.45 | 1.18 | 0.199 | 0.61 | 0.21 | 1.76 | 0.362 | 0.37 | 0.19 | 0.74 | 0.005 | 1.32 | 0.79 | 2.20 | 0.295 |
| Lymph node-positive | ||||||||||||||||||||
| No. of patients (no. of events) | 394 (145) | 206 (79) | 66 (25) | 46 (16) | 76 (25) | |||||||||||||||
| p-genes | ||||||||||||||||||||
| AURKA | 1.05 | 0.97 | 1.15 | 0.234 | 1.10 | 0.97 | 1.25 | 0.133 | 0.99 | 0.80 | 1.22 | 0.922 | 1.34 | 1.05 | 1.72 | 0.018 | 0.85 | 0.69 | 1.05 | 0.140 |
| CCNB2 | 1.13 | 0.97 | 1.32 | 0.126 | 1.33 | 1.07 | 1.65 | 0.010 | 1.12 | 0.74 | 1.68 | 0.594 | 1.08 | 0.65 | 1.80 | 0.771 | 0.74 | 0.47 | 1.15 | 0.179 |
| FOXM1 | 1.16 | 0.99 | 1.37 | 0.068 | 1.26 | 1.01 | 1.58 | 0.038 | 1.09 | 0.69 | 1.72 | 0.702 | 0.95 | 0.46 | 2.00 | 0.901 | 1.11 | 0.72 | 1.69 | 0.637 |
| MKI67 | 1.26 | 1.05 | 1.51 | 0.013 | 1.51 | 1.14 | 2.01 | 0.005 | 1.29 | 0.83 | 2.03 | 0.258 | 1.12 | 0.68 | 1.85 | 0.658 | 0.96 | 0.60 | 1.56 | 0.883 |
| MMP11 | 1.23 | 1.09 | 1.39 | 0.001 | 1.16 | 0.99 | 1.37 | 0.064 | 1.25 | 0.93 | 1.68 | 0.146 | 1.51 | 1.01 | 2.25 | 0.043 | 1.29 | 0.96 | 1.75 | 0.090 |
| PTTG1 | 1.00 | 0.81 | 1.22 | 0.967 | 1.02 | 0.77 | 1.35 | 0.903 | 1.37 | 0.84 | 2.23 | 0.213 | 0.96 | 0.47 | 1.97 | 0.908 | 0.74 | 0.42 | 1.30 | 0.293 |
| RACGAP1 | 1.15 | 0.96 | 1.37 | 0.137 | 1.22 | 0.96 | 1.54 | 0.100 | 1.33 | 0.79 | 2.23 | 0.286 | 0.83 | 0.45 | 1.53 | 0.551 | 1.04 | 0.69 | 1.56 | 0.859 |
| RRM2 | 1.14 | 0.96 | 1.34 | 0.128 | 1.26 | 1.00 | 1.58 | 0.046 | 1.66 | 1.07 | 2.58 | 0.024 | 0.81 | 0.46 | 1.41 | 0.453 | 0.86 | 0.61 | 1.22 | 0.402 |
| TOP2A | 1.16 | 1.05 | 1.29 | 0.005 | 1.29 | 1.11 | 1.50 | 0.001 | 1.20 | 0.94 | 1.54 | 0.152 | 0.91 | 0.63 | 1.30 | 0.594 | 0.92 | 0.69 | 1.24 | 0.591 |
| UBE2C | 1.18 | 1.02 | 1.36 | 0.023 | 1.32 | 1.08 | 1.60 | 0.006 | 1.30 | 0.88 | 1.94 | 0.192 | 0.81 | 0.46 | 1.40 | 0.442 | 1.04 | 0.77 | 1.40 | 0.802 |
| i-genes | ||||||||||||||||||||
| BTN3A2 | 1.01 | 0.84 | 1.22 | 0.905 | 1.05 | 0.81 | 1.38 | 0.702 | 1.15 | 0.68 | 1.94 | 0.609 | 0.65 | 0.34 | 1.25 | 0.193 | 1.06 | 0.72 | 1.57 | 0.769 |
| CCL19 | 0.98 | 0.87 | 1.11 | 0.756 | 1.02 | 0.86 | 1.20 | 0.856 | 0.94 | 0.70 | 1.27 | 0.682 | 0.93 | 0.68 | 1.28 | 0.670 | 0.98 | 0.73 | 1.31 | 0.884 |
| CD2 | 1.00 | 0.87 | 1.15 | 0.958 | 1.15 | 0.95 | 1.38 | 0.150 | 0.93 | 0.68 | 1.27 | 0.658 | 0.64 | 0.40 | 1.02 | 0.063 | 0.93 | 0.67 | 1.31 | 0.689 |
| CD52 | 0.98 | 0.96 | 1.01 | 0.167 | 0.99 | 0.96 | 1.03 | 0.646 | 0.97 | 0.90 | 1.05 | 0.470 | 0.97 | 0.91 | 1.04 | 0.395 | 0.98 | 0.93 | 1.04 | 0.478 |
| HLADPA1 | 1.02 | 0.89 | 1.17 | 0.767 | 0.98 | 0.82 | 1.17 | 0.811 | 1.03 | 0.72 | 1.45 | 0.885 | 0.93 | 0.65 | 1.33 | 0.688 | 1.26 | 0.86 | 1.85 | 0.242 |
| TRBC1 | 0.99 | 0.81 | 1.20 | 0.885 | 0.96 | 0.73 | 1.26 | 0.756 | 1.20 | 0.74 | 1.93 | 0.463 | 0.90 | 0.52 | 1.57 | 0.710 | 1.01 | 0.66 | 1.56 | 0.948 |
Hazard ratios with P values < 0.05 are marked in bold
HR hormone receptor, HER2 human epidermal growth factor receptor 2, TNBC triple-negative breast cancer, CI confidence interval, p-genes proliferation-related genes, i-genes immune response-related genes