Table 2.
Subject demographic and baseline characteristics
| Demographic characteristic | Adults (n = 33) | Pediatrics (n = 15) | All subjects (N = 48) |
|---|---|---|---|
| Age (years) | |||
| Mean (SD) | 39.5 (11.99) | 9.6 (4.15) | 30.1 (17.29) |
| Median (range) | 42.0 (17–55) | 8.5 (3–15) | 30.5 (3–55) |
| Age group, n (%) | |||
| 2–5 years | 0 | 2 (13.3) | 2 (4.2) |
| 6–11 years | 0 | 7 (46.7) | 7 (14.6) |
| 12–15 years | 0 | 6 (40.0) | 6 (12.5) |
| 16–55 years | 33 (100) | 0 | 33 (68.8) |
| Female, n (%) | 21 (63.6) | 7 (46.7) | 28 (58.3) |
| White, n (%) | 33 (100) | 15 (100) | 48 (100) |
| Diagnosis, n (%) | |||
| Common variable immunodeficiency | 30 (90.9) | 8 (53.3) | 38 (79.2) |
| X-linked and autosomal forms of agammaglobulinemia | 3 (9.1) | 5 (33.3) | 8 (16.7) |
| Hypogammaglobulinemia | 0 | 2 (13.3) | 2 (4.2) |
| Baseline chest X-ray/CT scan, n (%) | |||
| Normal | 28 (84.8) | 15 (100) | 43 (89.6) |
| Abnormala | 5 (15.2) | 0 | 5 (10.4) |
| Weight at screening (kg) | |||
| Mean (SD) | 78.81 (20.279) | 38.32 (16.028) | 66.15 (26.761) |
| Median (range) | 75.50 (51.6–140.0) | 34.70 (14.8–65.4) | 65.65 (14.8–140.0) |
CT computed tomography, CVID common variable immunodeficiency, SD standard deviation
aObserved abnormal chest X-ray/CT scans included a possible emphysematous change or hyperplasia involving the right upper lobe (judged to be not clinically significant), a chronic left lower lobe bronchiectasis, an elevation of the left hemidiaphragm, a subject with radiographic findings suggestive of pulmonary fibrosis (subject had a history of CVID-related lung disease), and a subject with minimal parenchymal scarring with parenchymal configuration that suggested chronic air trapping (no evidence of acute disease was noted)