Table 2.
The effects of RGTA® treatment in clinical cases or studies
| Condition or Procedure | Effects of RGTA® Treatment | References |
|---|---|---|
| Skin | ||
| Non-healing ulcers due to severe limb ischemia | -Increased healing, increased granulation tissue. −50 % ulcers healed after 3 months. |
Desgranges et al. [55] |
| Ischemia post-trauma | -Cases reports: rapid healing in finger and leg injuries. | Roohi (unpublished data); Desgranges et al. [55] |
| Sickle cell ulcer | -Case report: complete healing in a patient with a wound resistant to closure. | Hayek et al. [60] |
| Ulcers associated with Stewart-Bluefarb syndrome | -Case report: complete healing in a patient. | Hayek et al. [63] |
| Diabetic foot ulcers | -Complete wound closure in 60 % of patients and reduction in wound area in remaining patients. | Slim et al. [56] |
| Diabetic, pressure, vascular ulcers and burns | -Complete healing of 22 % of wounds at the end of the intervention period (up to 20 treatments sessions). -Reduction in wound size in remaining patients after 8 weeks. -Decreased pain. |
Groah et al. [57] |
| Diabetic foot ulcers | -Complete healing of patients (12/12) exhibiting chronic resistance to previous therapy within 4–6 months. | Papanas et al. [58] |
| Heat burn | -Complete healing after 4 months. | Barritault et al. [59] |
| Abrasive and electric burns | -Case reports: healing and growth of granulation tissue. | Roohi (unpublished data) |
| Lower extremity ulcers associated with epidermolysis bullosa | -Case report: healing of chronic, non-healing ulcers within 4 weeks. | Malaq and Denis [62] |
| Traumatic and plastic surgery | -Case report: healing and growth of granulation tissue. | Roohi (unpublished data) |
| Plastic surgery: mammary reduction | -Reduced inflammation, itching and scarring post-surgery. | Zakine and Le Louarn [64] |
| Plastic surgery: centrofacial lift | -Reduced inflammation, swelling and bruising. | Zakine and Le Louarn [64] |
| Scalp lesions following surgery | -Complete closure of the wound after 12 weeks. | van Neck et al. [61] |
| Cornea | ||
| Corneal neurotrophic ulcers | -Complete corneal healing in 72 % of patients after 8.7 weeks. -Decreased average ulcer area. |
Aifa et al. [65] |
| Corneal neurotrophic ulcer | -Case report: corneal healing in a patient resistant to previous treatments. | Pison et al. [66] |
| Corneal healing post corneal collagen crosslinking | -Enhanced re-epithelialization compared to control treated eyes. | Kymionis et al. [67] |
| Herpes zoster corneal neurotrophic ulcer | -Case report: complete corneal healing after 2 weeks. | De Monchy et al. [68] |
| Persistant epithelial ulcers | −11 eyes treated, pain relief and improvement in 9 cases. | Chebbi et al. [69] |
| Limbal graft failure | -Successful limbal allografts after previous failures. | Maringe et al. [70] |
| Corneal perforation associated with Sjogren’s disease | -Corneal healing in all five treated patients. | Renault et al. [71] |
| Epithelial basement membrane dystrophy | -Corneal healing in five of six treated patients. | Labetoulle et al. [72] |
| Dry eye associated with corneal superficial punctate keratitis | -Reduced pain and ulcer size. -Improved visual acuity. |
Gioganti-Aurégan (unpublished data) |
| Keratoconus | -Complete healing observed in 80 % of eyes (40 patients) compared to 15 % in the control group (p < 0.001). -Decreased ocular pain. |
Gumus [73] |
| Corneal ulcer in a child with aniridia | -Corneal healing observed within 15 days. | Chiambaretta (unpublished data) |