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Extracapillary proliferative lesions consisting in parietal epithelial cells (PECs) in glomeruli of patients with focal and segmental glomerulosclerosis (FSGS; a) and crescentic glomerulonephritis (CrGN; b). Double immunostaining for claudin-1 expressed by PECs (green, arrowheads) and specific heparan sulfates in the extracellular matrix (red). Note marked hyperplasia of claudin-1-positive PECs (arrows) in both FSGS and CrGN
