Table 1.
Sociodemographic and disease baseline features
| Variable | Cohort 1: fertile women | Cohort 2: age-matched men (to fertile women) | Cohort 3: postmenopausal women | Cohort 4: age-matched men (to postmenopausal women) |
|---|---|---|---|---|
| N | 336 | 253 | 182 | 118 |
| Age (years), mean (SD) | 35.56 (9.03) |
(p = 0.039)§ 37.06 (8.78) |
57.13 (5.68) |
(p = 0.011)# 55.46 (6.07) |
| Age group, n | ||||
| 18–34 | 151 | 94 | 0 | 0 |
| 35–44 | 124 | 110 | 1 | 1 |
| 45–54 | 60 | 48 | 58 | 46 |
| 55+ | 1 | 1 | 123 | 71 |
| Education, n (%)* | (p = 0.099)§ | (p = 0.234)# | ||
| None | 0 (0.0) | 0 (0.0) | 2 (1.1) | 1 (0.8) |
| Primary school | 8 (2.4) | 10 (4.0) | 35 (19.2) | 15 (12.7) |
| Lower secondary | 90 (26.8) | 79 (31.2) | 62 (34.1) | 51 (43.2) |
| Upper secondary | 175 (52.1) | 133 (52.6) | 60 (33.0) | 40 (33.9) |
| Bachelor degree | 54 (16.1) | 25 (9.9) | 18 (9.9) | 8 (6.8) |
| Caucasian race, N (%) | 328 (97.6%) |
(p = 0.395)§ 243 (96.0%) |
178 (97.8%) |
(p = 0.453)# 117 (99.2%) |
| Age at diagnosis (years), mean (SD) | 23.81 (10.59) |
(p = 0.371)§ 24.87 (10.18) |
40.85 (13.61) |
(p = 0.813)# 40.74 (13.01) |
| Disease duration (years), mean (SD) | 12.13 (10.08) |
(p = 0.366)§ 12.58 (9.11) |
16.75 (12.97) |
(p = 0.120)# 15.12 (10.82) |
| PASI at enrollment, n (%)* | (p = 0. 836)§ | (p = 0.272)# | ||
| ≤20 | 258 (84.6) | 192 (83.5) | 132 (81.5) | 90 (80.4) |
| 21–29 | 35 (11.5) | 30 (13.0) | 22 (13.6) | 20 (17.9) |
| ≥30 | 12 (3.9) | 8 (3.5) | 8 (4.9) | 2 (1.8) |
| Months from CSA start, mean (SD) | 40.76 (42.19) |
(p = 0.772)§ 41.58 (39.97) |
48.39 (52.60) |
(p = 0.140)# 37.74 (47.02) |
| No. of previous CSA cycles, mean (SD; min–max) | 2.09 (1.71; 1–10) |
(p = 0.684)§ 2.19 (2.07; 1–14) |
1.98 (1.44; 1–7) |
(p = 0.0684)# 2.60 (2.08; 1–10) |
| No. of days of CSA treatment, mean (SD) | 130.00 (54.13) |
(p = 0.009)§ 141.40 (51.28) |
122.59 (54.62) |
(p = 0.007)# 140.0 (54.89) |
The t test for equal variances was considered for continuous variables, Chi-squared test for categorical variables
* Percentages are computed on the basis on patients with available data
§Fertile women vs. age-matched men (to fertile women)
#Postmenopausal women vs. age-matched men (to postmenopausal women)