Table 4.
Hormone levels in the different study populations, stratified by presence or absence of adverse effects (AEs)
| Hormone | With no AEs | With ≥1 AEs | p value |
|---|---|---|---|
| Fertile women | |||
| 17-beta-estradiol (pg/mL) | 32.71 (21.84; 54.92) | 33.17 (19.60; 49.78) | |
| FSH (mIU/mL) | 6.68 (4.55; 9.59) | 6.83 (4.71; 10.74) | |
| LH (mIU/mL) | 9.36 (6.22; 12.91) | 8.69 (5.11; 12.56) | |
| DHEA sulfate (mg/mL) | 147.00 (94.00; 228.00) | 157.50 (108.00; 256.50) | 0.2683 |
| Cortisol (mg/dL) | 12.05 (8.32; 17.61) | 11.18 (7.85; 15.34) | |
| Testosterone (ng/dL) | 51.00 (34.00; 68.00) | 55.50 (44.00; 68.00) | |
| Free testosterone (pg/mL) | 1.06 (0.46; 2.20) | 1.10 (0.56; 2.55) | |
| Postmenopausal women | |||
| 17-beta-estradiol (pg/mL) | 16.39 (11.06; 27.67) | 14.99 (10.81; 31.18) | |
| FSH (mIU/mL) | 60.59 (45.67; 91.05) | 54.01 (38.70; 79.76) | 0.0284 |
| LH (mIU/mL) | 42.05 (33.11; 53.11) | 42.51 (30.41; 52.72) | |
| DHEA sulfate (mg/mL) | 83.00 (47.00; 120.00) | 71.00 (43.00; 126.00) | 0.4575 |
| Cortisol (mg/dL) | 12.85 (9.49; 17.02) | 10.69 (7.41; 14.96) | 0.0274 |
| Testosterone (ng/dL) | 44.50 (31.00; 61.50) | 42.00 (28.00; 57.00) | 0.1755 |
| Free testosterone (pg/mL) | 0.78 (0.37; 1.52) | 0.51 (0.13; 1.12) | |
| Men | |||
| 17-beta-estradiol (pg/mL) | 19.86 (13.65; 30.06) | 19.26 (14.89; 34.23) | |
| FSH (mIU/mL) | 4.22 (2.98; 6.49) | 4.87 (3.32; 6.36) | |
| LH (mIU/mL) | 7.67 (5.48; 10.20) | 6.99 (5.36; 10.00) | |
| DHEA sulfate (mg/mL) | 197.00 (123.00; 341.00) | 181.00 (116.00; 277.00) | |
| Cortisol (mg/dL) | 11.42 (8.73; 15.72) | 11.25 (8.44; 15.62) | |
| Testosterone (ng/dL) | 404.00 (319.00; 513.00) | 387.00 (288.00; 463.00) | 0.0827 |
| Free testosterone (pg/mL) | 9.50 (6.30; 14.54) | 9.61 (5.33; 14.12) | |
Values are expressed as median (25th percentile; 75th percentile)
Wilcoxon test was calculated to test clinically relevant differences