Figure 4.

Graphical representation of the tumor volume evolution (in mm³, black line, left axis), and the percentage of responding “green” pixels obtained after source analysis of MRSI data acquired in the multi-slice set as in [13] (in percent, green dots, right axis) of HR cases. The green shaded columns indicate TMZ administration periods. For chosen time points, the evolution of the nosological images obtained with the semisupervised source extraction system is shown, superimposed to the T_2w-MRI for each slice. The number of grids (3 or 4) depended of the coverage of the tumor: if tumor was totally covered with three grids, no additional grids were acquired. (A) Corresponds to the case C1100: green pixels were observed in Grids 1 and 2 with a TRI = 36.8% at Day 21 p.i. during tumor growth arrest. Then at Day 26 p.i., tumor volume decreased and a TRI of 61.8% was observed. (B) Corresponds to the case C1108: green pixels were observed in Grids 1 and 2 with a TRI = 70.3% when tumor volume decrease was observed.