Table 2.
Bile acid levels in mouse plasma.
| Bile Acid | 6 Months | 12 Months | ||||||
|---|---|---|---|---|---|---|---|---|
| Control (n = 5) | APP/PS1 (n = 5) | p-Value | ROC | Control (n = 5) | APP/PS1 (n = 5) | p-Value | ROC | |
| CA | 1811 ± 368 | 10510 ± 4498 | 0.05 | 0.80 | 2934 ± 1247 | 2099 ± 763 | 0.45 | 0.52 |
| CDCA | 142 ± 44 | 392 ± 189 | 0.18 | 0.68 | 300 ± 66 | 197 ± 90 | 0.17 | 0.68 |
| DCA | 970 ± 331 | 3799 ± 2247 | 0.08 | 0.80 | 1569 ± 431 | 1642 ± 422 | 0.37 | 0.52 |
| GCA | <LLOQ | <LLOQ | 0.19 | - | <LLOQ | <LLOQ | - | - |
| GCDCA | <LOD | <LOD | - | - | <LOD | <LOD | - | - |
| GDCA | <LOD | <LOD | - | - | <LOD | <LOD | - | - |
| GLCA | <LOD | <LOD | - | - | <LOD | <LOD | - | - |
| GLCAS | <LLOQ | <LLOQ | - | - | <LLOQ | <LLOQ | - | - |
| GUDCA | <LLOQ | <LLOQ | - | - | <LLOQ | <LLOQ | - | - |
| HDCA | 609 ± 214 | 405 ± 125 | 0.20 | 0.64 | 1009 ± 226 | 364 ± 192 | 0.04 | 0.87 |
| LCA | 40 ± 10 | 64 ± 32 | 0.32 | 0.56 | 77 ± 15 | 88 ± 32 | 0.48 | 0.52 |
| α-MCA | 88 ± 50 | 211 ± 103 | 0.13 | 0.65 | 391 ± 176 | 136 ± 73 | 0.37 | 0.72 |
| β-MCA | 3132 ± 977 | 8780 ± 3781 | 0.10 | 0.76 | 4271 ± 1706 | 4716 ± 1258 | 0.30 | 0.60 |
| Ω-MCA | 3068 ± 1035 | 5246 ± 2189 | 0.24 | 0.68 | 2368 ± 1213 | 1235 ± 332 | 0.42 | 0.52 |
| TCA | 865 ± 251 | 9473 ± 9007 | 0.36 | 0.60 | 1258 ± 244 | 1051 ± 331 | 0.31 | 0.53 |
| TCDCA | 52 ± 10 | 610 ± 575 | 0.36 | 0.58 | 87 ± 15 | 68 ± 17 | 0.18 | 0.70 |
| TDCA | 143 ± 40 | 912 ± 822 | 0.34 | 0.52 | 159 ± 11 | 188 ± 43 | 0.40 | 0.60 |
| TLCA | <LLOQ | <LLOQ | - | - | <LLOQ | <LLOQ | - | - |
| TLCAS | <LLOQ | <LLOQ | - | - | <LLOQ | <LLOQ | - | - |
| TMCA (α + β) | 1529 ± 322 | 5406 ± 4260 | 0.38 | 0.52 | 1326 ± 318 | 1408 ± 384 | 0.44 | 0.52 |
| TUDCA | 347 ± 72 | 1723 ± 1582 | 0.42 | 0.68 | 990 ± 437 | 513 ± 221 | 0.22 | 0.76 |
| UDCA | 363 ± 150 | 1348 ± 784 | 0.10 | 0.72 | 693 ± 179 | 838 ± 287 | 0.26 | 0.52 |
Concentrations presented are nM (mean ± SEM). <LOD = Below the limit of detection. <LLOQ = Below the lower limit of quantification. ROC = Receiver operating characteristic. Significant p-values are in bold.